REJUBEAU EXO Skin Booster

UNDERSTANDING EXOSOMES

Exosomes might be tiny, but their role in the world of aesthetics is anything but small. These minuscule vesicles,

ranging from 30 to 150 nanometers in size, are produced by various cells in our body and serve as essential messengers

of communication. They carry powerful ingredients, including genetic material, proteins, and other molecules, and

travel throughout the body, delivering these precious cargoes to target cells.

One of the interesting features of exosomes is their ability to transfer genetic material, particularly microRNAs, which

are like tiny conductors of a genetic orchestra. These microRNAs can tune up or down the expression of genes within

the recipient cells, regulating their behavior and encouraging them to act in a more youthful and vibrant manner.

According to studies, Exosomes may have the power to turn back the clock on aging cells, prompting them to behave

like they did when we were younger. This means they can boost collagen and elastin production, improve skin texture,

reduce the appearance of wrinkles, and even promote hair growth.

• 100% Concentrated and
• Purified Exosome Booster
• for Skin and Hair
• More Powerful
• More Pluripotent
• Clear-Cut Effect

INTERCELLULAR COMMUNICATION

Exosomes act as messengers in the intercellular communication network of the body. They are secreted by various

cell types, including stem cells, and are released into the extracellular environment. These exosomes carry a diverse

payload of molecules, including microRNAs, mRNAs, proteins, and lipids. These molecular components are selectively

packaged within the exosomes, allowing them to target specific cells and influence cellular behavior.

CELLULAR UPTAKE

Upon reaching the target tissue, exosomes interact with recipient cells by binding to their surface receptors. This

interaction facilitates the internalization of exosomes into the target cells, where the encapsulated bioactive molecules

are released and begin to exert their effects

GENETIC REGULATION

One of the most significant contributions of exosomes in aesthetics is their ability to transfer genetic material,

specifically microRNAs, to recipient cells. MicroRNAs are short, non-coding RNA molecules that play a vital role

in regulating gene expression. By delivering specific microRNAs to the target cells, exosomes can modulate the

expression of genes involved in cell growth, tissue repair, and collagen synthesis.

STIMULATION OF CELL PROLIFERATION AND DIFFERENTIATION

Exosomes promote the proliferation and differentiation of target cells, thereby encouraging tissue regeneration.

For instance, in facial rejuvenation procedures, exosomes delivered into the skin can stimulate the proliferation of

fibroblasts. The fibroblast cells are responsible for producing collagen and elastin. This increase in collagen and elastin

production leads to improved skin elasticity, reduced wrinkles, and an overall more youthful appearance.

SUPPRESSION OF INFLAMMATION

Inflammation is a common response to tissue damage or injury, but excessive or chronic inflammation can be

detrimental to the skin. Exosomes have demonstrated anti-inflammatory properties, which can help reduce skin

redness, irritation, and swelling. By modulating the inflammatory response, exosomes promote a calmer and more

balanced environment in the treated tissues.

COLLAGEN AND ELASTIN REMODELING

Exosomes play a role in collagen and elastin remodeling, which is vital in maintaining skin structure and elasticity.

Collagen and elastin production declines with age, causing the skin to sag and wrinkle. By boosting the synthesis of

fresh collagen and elastin fibers and their appropriate alignment within the skin matrix, exosomes can reverse this

process in its tracks.

REJUBEAU EXO SB & HB 100%

100% Concentrated and Purified Exosome Booster for Skin and Hair

Customizing stem cells for intended purpose with priming factor iPSC (induced pluripotent stem cell)-derived

MSCs (mesenchymal stem cells) represent a type of stem cell that is generated by reprogramming umbilical cord

blood into pluripotent stem cells and then differentiated into mesenchymal stem cells. It is called iMSC (induced

mesenchymal stem cell).

Alleviate Inflammation

Relieve Dermatitis: skin spot / acne prone skin / problematic skin

Activate skin cell and thicken dermis layer

Improve skin elasticity, fine & deep wrinkles, sagging pores and

rejuvenates skin

Regenerate skin cell and antiaging

Promote the proliferation of Elastin, Collagen, Hyaluronic Acid

Improve skin tone

Promote more radiant and young toned complexion

Skin Booster 100 Stem Cell : 300 mg x 1 vial

Activating Solution : 5 ml x 1 vial

PROTOCOL

General Guidance

1. Mix EXO SB 100% Exosome powder (300mg) with EXO SB 100% Activating solution (5ml).

2. Cleanse the area to be treated thoroughly

3. Apply the mixture to the skin and allow it to be absorbed thoroughly into the skin by MTS device

like a Derma roller or a Derma pen.

4. After the treatment, gently massage the residue to allow it to be absorbed into the skin and apply

calming mask

5. Apply calming and regenerating serum as a post-care.

6. Number of treatment sessions:

1) Intensive phase: 1 treatment a week for 5 weeks for skin.

(It can be different depending on patient status)

2) Maintenance phase: 1 treatment a month or if necessary

▶ In case the blended solution causes any trouble to sensitive patients, the alternative guidance is

recommended.

Full Hydration

1. After mixing EXO’s Exosome powder (300mg) with EXO’s Activating solution (5ml), shake it

sufficiently and leave it for 2 or 3 minutes for full hydration

2. The mixed solution should be used within 3 hours and stored in a refrigerator.

Alternative Guidance for Sensitive Skin

1. Mix EXO’s Exosome powder (300mg) with Normal Saline (4 or 5 ml).

2. Apply the mixed solution to the skin after treating with an MTS device like derma roller or Derma

pen. After the treatment, the patient can use the EXO’s Activating solution (5ml) at home topically.

Alternative Guidance [Japan only]

1. Blend EXO’s Exosome powder (300mg) with Normal Saline (4 ml)

2. Treat by using MTS Injector

▶After the treatment, the patient can use the EXO’s Activating solution (5ml) at home topically.

▶This guidance is suggested for the Japanese market only.

Storage

▶EXO’s Exosome powder should be stored in the refrigerator (2~6℃ )

▶ Check the Exosome powder condition before hydration.

White is normal. If the Exosome powder shows browning, do not use it and discard it.

Hair Booster 100 Stem Cell : 300 mg x 1 vial

Activating Solution : 5 ml x 1 vial

SCALP

-Hydrate and nourish the scalp

-Promote a healthy hair growth cycle

-Noticeably reduce hair loss

-Visibly make hair look and feel soft, shiny, and full

PROTOCOL

General Guidance

1. Mix EXO HB 100% Exosome powder (300mg) with EXO HB 100% Activating solution (5ml).

2. Cleanse the area to be treated thoroughly.

3. Apply the mixture to the scalp and allow it to be absorbed thoroughly into the skin by MTS device

like a Derma roller or a Derma pen.

4. After the treatment, gently massage the residue to allow it to be absorbed into the skin.

5. Number of treatment sessions:

1) Intensive phase: 1 treatment a week for 10 weeks for hair.

(It can be different depending on patient status)

2) Maintenance phase: 1 treatment a month or if necessary.

▶ In case the blended solution causes any trouble to sensitive patients, the alternative guidance is

recommended.

Full Hydration

1. After mixing EXO’s Exosome powder (300mg) with EXO’s Activating solution (5ml), shake it

sufficiently and leave it for 2 or 3 minutes for full hydration

2. The mixed solution should be used within 3 hours and stored in a refrigerator.

Alternative Guidance for Sensitive Skin

1. Mix EXO’s Exosome powder (300mg) with Normal Saline (4 or 5 ml).

2. Apply the mixed solution to the skin after treating with an MTS device like derma roller or

Derma pen.

▶After the treatment, the patient can use the EXO’s Activating solution (5ml) at home topically.

Alternative Guidance [Japan only]

1. Mix EXO’s Exosome powder (300mg) with Normal Saline (4 ml)

2. Treat by using MTS Injector

▶After the treatment, the patient can use the EXO’s Activating solution (5ml) at home topically.

▶ This guidance is suggested for Japanese market only.

Storage

EXO’s Exosome powder should be stored in the refrigerator (2~6℃ )

Check the Exosome powder condition before hydration. White is normal. If the Exosome powder

shows browning, do not use it and discard it.